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Beef and Salsa Casserole Recipe

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This beef and salsa casserole is not too spicy for little kids and is the perfect dinner recipe for Cinco de Mayo! It can be thrown together quickly and even done beforehand!

If you want a hearty casserole dish loaded with flavor, add this easy recipe to your list. It’s full of beef, corn, beans, and tortilla chips—what more could you want?

Making a simple casserole is a great way to feed the whole family. It’s loaded with simple ingredients, making it an easy, stress-free dinner!

Beef and Salsa Casserole

I’ve been a fan of making homemade casseroles for years. Not only do they feed a crowd, but they’re also a great way to ensure that you’ll have leftovers.

Reheating leftover casseroles is a simple way to stretch a meal – and make the ingredients stretch further, too!

You can easily make this hearty beef casserole for a Mexican-themed dinner or a fun fiesta-themed meal at home. Just be sure to have toppings on hand so everyone can enjoy the flavors they want.

What side dishes pair with beef casserole recipes?

A refreshing garden salad with a variety of leafy greens offers a crisp contrast to the casserole’s rich flavors. Steamed or roasted vegetables, like carrots, broccoli, and Brussels sprouts, are healthful and colorful.

For those who enjoy a starchier accompaniment, garlic mashed potatoes or buttery egg noodles can round out the dinner plate.

Rustic bread, such as a crusty baguette, is a delightful option for sopping up savory juices and adding a textural difference.

For a comforting finish, consider a side of roasted sweet potatoes that add a hint of sweetness to balance the robustness of beef casserole dishes.



Specialty Ingredients:

The following ingredients are affiliate links on Amazon because they may be a bit hard to find in your normal store.  I wanted you to be able to see exactly which things we are using.

Reminder, not all ingredients in the Mexican Casserole Recipe are linked above, just the ones that may be a bit difficult to find or that you might be unsure of what to look for

Shop My Kitchen:

The following items can be found in my kitchen here at Miller Manor. Simply click the image that interests you – yes, they do contain affiliate links.

Must Have Resources:

When making Salsa and Beef Casserole at home, you really need to have the following Amazon affiliate tools on hand.



Make it a Meal:

Use this as the boost that you need to kickstart meal planning! It’s a fun and simple process to make meals for the family – and stop stressing about it!

Vegetable Side: Keto Creamy Brussels Sprouts Bake Recipe

Starch Side: Oven Roasted Red Potatoes Recipe

Refreshing Drink: Pumpkin Punch Recipe

Don’t forget Dessert: Vanilla Puppy Chow Recipe

Best Casserole Recipes:

Once you make this Mexican Beef Casserole Recipe, add more casserole recipes to your meal-planning radar. Here are a few of my top picks!

Gather the simple ingredients to make this Pork Chop and Rice Casserole Recipe!

I love feeding a crowd by making this Loaded Baked Potato Casserole Recipe. So good!

Biscuits and Gravy Casserole is the perfect way to start the day!

Make this Pressure Cooker Green Bean Casserole for your next family gathering!

This Beef, Rice and Bean Casserole is a quick, easy weeknight meal!

Everyone in my house agrees that this Mediterranean Turkey Casserole Recipe has great flavor.

This Grinch Breakfast Casserole Recipe is a great morning recipe for the holidays!

How do I reheat leftover casserole?

Reheating a leftover casserole can be as much an art as preparing it, ensuring the meal retains its flavor and texture. The best method is to utilize your oven to reheat it evenly without drying it out.

Begin by preheating the oven to 350 degrees. Cover the casserole with aluminum foil to prevent the top from burning and to lock in moisture. Place the dish in the oven once it’s reached the desired temperature.

Heating times can vary based on the casserole’s thickness, but generally, it should take approximately 20-30 minutes. It’s ready when the internal temperature hits 165 degrees Fahrenheit, ensuring it’s heated through.

Remove the foil in the last 5-10 minutes of reheating for a crispier top. Always check the center of the casserole, as that’s the last part to warm up thoroughly.

Shop My Printables

These printables are great for meal planning and organizing! Simply click the image to check out my shop products!

More Beef Recipes:

Beef and Salsa Casserole for Cindo de Mayo!

Beef and Salsa Casserole for Cindo de Mayo!

Yield: 6
Prep Time: 15 minutes
Cook Time: 20 minutes
Total Time: 35 minutes

This beef and salsa casserole can be thrown together pretty quickly and can even be done ahead of time!


  • 1 lb ground beef or ground chuck for less fat
  • 1 cup frozen corn thawed and drained
  • 2 cups tortilla chips
  • 2 cups shredded Monterey Jack cheese
  • 12 ounce chunky salsa
  • 3/4 cup mayonnaise
  • 1 ½ tbsp. chili powder
  • seasoned salt to taste
  • black pepper to taste


  1. Preheat oven to 350 degrees.
  2. In a large skillet over medium heat, add the beef, seasoned salt, chili powder and black pepper.
  3. Brown the beef until fully cooked and then drain off the fat.
  4. Add the corn, mayonnaise and salsa and stir to blend.
  5. Using a 2 quart casserole dish, layer the ingredients, distributing evenly, as follows.
  6. ½ of the meat
    ½ of the chips
    ½ of the cheese
  7. Repeat with remaining ingredients.
  8. Cover with aluminum foil and bake for 20 minutes.
  9. Serve immediately with chopped tomatoes, shredded lettuce, and sour cream if you’d like.
Nutrition Information:
Yield: 6 Serving Size: 1
Amount Per Serving: Calories: 685Total Fat: 51gSaturated Fat: 17gTrans Fat: 1gUnsaturated Fat: 30gCholesterol: 129mgSodium: 1047mgCarbohydrates: 19gFiber: 3gSugar: 4gProtein: 38g

This data was provided and calculated by Nutritionix on 3/30/2020

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Thursday 25th of April 2013

Delicious way to celebrate Cinco de Mayo and just for regular dinners.

Pam Brown Margolis

Wednesday 24th of April 2013

That looks and sounds so delicious!!!!!

Kirby Burt @Authentic Mexican Recipes

Tuesday 23rd of April 2013

This recipe sounds DELISH!. I will definitely try this out for Cinco de Mayo.

Lindsay @ Laughing Lindsay

Tuesday 23rd of April 2013

Sounds delicious and perfect for Cinco de Mayo. I'll have to check it out.

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