Preheat the oven to 350 degrees. Mix the cake mix and eggs, oil, and water in a bowl.
Use a different bowl and mix the cream cheese, vanilla, and sugar.
Spray the muffin pan with spray and then add in 1 T of the brownie batter. Use a different spoon and put 1 tsp of the cream cheese mixture on top of that. Grab a clean toothpick and swirl the mixture.